CHD1L

Across TCGA patient cohorts, CHD1L mutation is significantly associated with the RNA expression of many other genes, with 1,079 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHD1L-associated genes across cancer lineages are MIR548AW, RNU6-905P, and ZMAT1. Each is linked with CHD1L in more than 2 cancer types. Because this analysis shows association rather than direction, both CHD1L-to-partner and partner-to-CHD1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548AW grouped by CHD1L-low versus CHD1L-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD1L→partner) and Y-score (partner→CHD1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR548AW →	+0.200	+4.201	<.001	.007	3	3
SKCM	RNU6-905P →	+0.144	+3.098	.004	.008	3	3
UCEC	ZMAT1 →	-0.653	-2.523	.001	<.001	3	2
UCEC	LPL →	-0.518	-1.807	.005	.004	3	2
UCEC	RIC8A →	+0.302	+2.032	.007	.005	3	2
SKCM	NCAPH2 →	+0.530	+3.208	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,079 associations by consensus.

MIR548AW by CHD1L expression — BRCA

Explore this box plot interactively →