CHD1L

Across TCGA pan-cancer cohorts, CHD1L RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CHD1L data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CHD1L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHD1L expression acts as an unfavorable survival marker, although some lineages such as READ and PAAD show a favorable association.

ACC, KIRP, and LIHC are the cancer types where CHD1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.236	0.621	<.001	117	view →
KIRP	DFS	Tertile	All	0.613	0.797	.001	117	view →
LIHC	OS	Median	All	0.609	0.762	<.001	84	view →
LUAD	DFS	Quartile	All	0.680	0.900	<.001	62	view →
KIRC	DFS	Quartile	II,III,IV	0.397	0.615	.003	54	view →
KICH	OS	Quartile	II,III,IV	0.357	0.933	<.001	44	view →
MESO	OS	Tertile	III,IV	0.405	0.680	.003	40	view →
HNSC	OS	Quartile	All	0.308	0.497	.005	31	view →
READ	OS	Median	II,III,IV	0.821	0.463	.007	21	view →
CESC	DFS	Quartile	III,IV	0.434	0.826	.018	20	view →
SARC	DFS	Median	All	0.423	0.600	<.001	18	view →
ESCA	DFS	Quartile	III,IV	0.269	0.547	.008	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CHD1L–ACC (DFS)

Open the ACC breakdown →