CHD1L

Across TCGA patient cohorts, CHD1L mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHD1L-associated genes across cancer lineages are p62 Lck ligand, cIAP, and FOXO3a_pS318_S321. Each is linked with CHD1L in more than 1 cancer types. Because this analysis shows association rather than direction, both CHD1L-to-partner and partner-to-CHD1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CHD1L-low versus CHD1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD1L→partner) and Y-score (partner→CHD1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.489	+3.817	<.001	<.001	3	2
UCEC	cIAP →	+0.102	+3.469	.048	.002	3	2
UCEC	FOXO3a_pS318_S321 →	-0.096	-1.990	.040	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.176	-2.807	.005	.003	3	1
UCEC	Ku80 →	+0.218	+1.428	.014	.029	3	1
UCEC	Notch1 →	+0.144	+1.598	.006	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

p62 Lck ligand by CHD1L expression — UCEC

Explore this box plot interactively →