CHD1

Across TCGA patient cohorts, CHD1 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHD1-associated genes across cancer lineages are Collagen-VI, Cyclin-B1, and PTEN. Each is linked with CHD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CHD1-to-partner and partner-to-CHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Collagen-VI grouped by CHD1-low versus CHD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD1→partner) and Y-score (partner→CHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Collagen-VI →	-0.153	-1.912	.008	.004	3	3
UCEC	Cyclin-B1 →	+0.557	+2.459	<.001	<.001	3	3
STAD	PTEN →	+0.499	+3.000	.021	.036	1	4
COAD	MEK1 →	+0.336	+3.025	.001	.019	3	2
COAD	Bim →	+0.298	+3.008	.033	.019	3	2
UCEC	4E-BP1 →	+0.330	+3.321	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Collagen-VI by CHD1 expression — UCEC

Explore this box plot interactively →