CHD1

Across TCGA cell cohorts, CHD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,853 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHD1-associated GO terms across cancer lineages are Positive regulation of rRNA processing, Microtubule organizing center organization, and Centriole replication. Each is linked with CHD1 in more than 15 cancer types. Because this analysis shows association rather than direction, both CHD1-to-partner and partner-to-CHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of rRNA processing grouped by CHD1-low versus CHD1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD1→partner) and Y-score (partner→CHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of rRNA processing →	+0.131	+0.621	<.001	.008	3	16
UPPER_AERODIGESTIVE_TRACT	Microtubule organizing center organization →	+0.085	+1.015	<.001	<.001	3	15
BONE	Centriole replication →	+0.126	+0.650	<.001	.002	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of centrosome duplication →	+0.503	+0.706	.002	<.001	3	15
LARGE_INTESTINE	Regulation of centrosome duplication →	+0.084	+0.911	<.001	<.001	3	14
BONE	Double-strand break repair →	+0.072	+0.656	.003	.002	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,853 associations by consensus.

Positive regulation of rRNA processing by CHD1 expression — OESOPHAGUS

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