CHD1

Across TCGA cell cohorts, CHD1 mutation is significantly associated with the RNA expression of many other genes, with 2,109 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHD1-associated genes across cancer lineages are MAST1, UFSP2, and AKAP3. Each is linked with CHD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHD1-to-partner and partner-to-CHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAST1 grouped by CHD1-low versus CHD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD1→partner) and Y-score (partner→CHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAST1 →	+0.769	+3.321	.002	.003	3	2
LARGE_INTESTINE	UFSP2 →	+0.625	+2.743	<.001	.001	3	2
LARGE_INTESTINE	AKAP3 →	+0.625	+3.087	.004	.006	3	2
LARGE_INTESTINE	MDN1 →	+0.654	+3.459	<.001	.001	3	2
LARGE_INTESTINE	TBP →	+0.507	+2.743	.005	.001	3	2
LARGE_INTESTINE	TXNDC15 →	+0.571	+2.743	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,109 associations by consensus.

MAST1 by CHD1 expression — LARGE_INTESTINE

Explore this box plot interactively →