CHCHD4P2

Across TCGA pan-cancer cohorts, CHCHD4P2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CHCHD4P2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CHCHD4P2 RNA is repressed in tumor relative to normal tissue. In most cancer types CHCHD4P2 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, KIRC, and THCA are the cancer types where CHCHD4P2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHCHD4P2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.206	<.001	9	view →
KIRC	All	All	+0.048	<.001	7	view →
THCA	Female	All	−0.029	.015	3	view →
LUSC	Male	All	+0.096	.002	2	view →
KIRP	All	All	+0.050	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CHCHD4P2–COAD

Open the COAD breakdown →