CHCHD4

Across TCGA pan-cancer cohorts, CHCHD4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CHCHD4 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CHCHD4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CHCHD4 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, HNSC, and UCEC are the cancer types where CHCHD4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	All	1.000	0.806	.037	30	view →
HNSC	DFS	Quartile	II,III,IV	0.685	0.914	.010	12	view →
UCEC	DFS	Median	All	0.776	0.919	.027	6	view →
PDAC	DFS	Median	II,III,IV	0.457	0.327	.034	5	view →
CCRCC	DFS	Tertile	All	0.563	0.876	.017	4	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →
LSCC	OS	Median	II,III,IV	1.000	0.884	.022	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CHCHD4–COAD (DFS)

Open the COAD breakdown →