CHCHD4

Across TCGA pan-cancer cohorts, CHCHD4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CHCHD4’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where CHCHD4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHCHD4 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

LIHC, KIRC, and BRCA are the cancer types where CHCHD4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHCHD4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.100	<.001	9	view →
KIRC	Male	All	−0.446	<.001	9	view →
BRCA	All	All	+0.154	.003	6	view →
THCA	Male	II,III,IV	−0.366	.014	5	view →
STAD	All	II,III,IV	+0.381	.006	4	view →
KIRP	Male	All	−0.352	<.001	4	view →
CHOL	All	All	+0.843	.006	2	view →
LUAD	Male	III,IV	+0.649	.014	2	view →
BLCA	All	All	+0.410	.039	2	view →
COAD	All	All	+0.267	.009	2	view →
LUSC	Female	II,III,IV	−0.342	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CHCHD4–LIHC

Open the LIHC breakdown →