CHCHD4

Across TCGA patient cohorts, CHCHD4 protein abundance is significantly associated with the RNA expression of many other genes, with 8,073 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CHCHD4-associated genes across cancer lineages are TMEM45A, FCAR, and TNFAIP6. Each is linked with CHCHD4 in more than 5 cancer types. Because this analysis shows association rather than direction, both CHCHD4-to-partner and partner-to-CHCHD4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHCHD4 versus TMEM45A in BRCA, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHCHD4→partner) and Y-score (partner→CHCHD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TMEM45A →	-1.171	-0.430	<.001	.002	3	6
GBM	FCAR →	-0.804	-0.395	.002	<.001	3	6
LSCC	TNFAIP6 →	-1.212	-0.310	<.001	.001	3	5
HNSC	TREM1 →	-1.134	-0.384	<.001	<.001	3	5
LSCC	FCGR3B →	-1.315	-0.240	<.001	.002	3	5
HNSC	PROK2 →	-1.220	-0.386	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,073 associations by consensus.

CHCHD4 vs TMEM45A — BRCA

Explore this scatter interactively →