CHCHD4

Across TCGA patient cohorts, CHCHD4 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHCHD4-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and FoxM1. Each is linked with CHCHD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHCHD4-to-partner and partner-to-CHCHD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CHCHD4-low versus CHCHD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHCHD4→partner) and Y-score (partner→CHCHD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.323	-2.459	.007	.020	3	1
UCEC	eIF4E →	+0.272	+2.459	.007	.020	3	1
UCEC	FoxM1 →	+0.268	+2.459	.032	.020	3	1
UCEC	MEK1 →	+0.473	+3.321	.007	.010	3	1
UCEC	p62 Lck ligand →	+0.474	+2.459	.002	.020	3	1
UCEC	VHL →	-1.548	-3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by CHCHD4 expression — UCEC

Explore this box plot interactively →