CHCHD4

Across TCGA cell cohorts, CHCHD4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,693 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CHCHD4-associated GO terms across cancer lineages are Protein import into mitochondrial intermembrane space, Mitochondrial disulfide relay system, and tRNA-type intron splice site recognition and cleavage. Each is linked with CHCHD4 in more than 19 cancer types. Because this analysis shows association rather than direction, both CHCHD4-to-partner and partner-to-CHCHD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein import into mitochondrial intermembrane space grouped by CHCHD4-low versus CHCHD4-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHCHD4→partner) and Y-score (partner→CHCHD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Protein import into mitochondrial intermembrane space →	+0.162	+1.348	<.001	<.001	3	20
LUNG_SCLC	Mitochondrial disulfide relay system →	+0.172	+1.015	<.001	<.001	3	20
SKIN	tRNA-type intron splice site recognition and cleavage →	+0.100	+0.772	<.001	<.001	3	17
BREAST	Mitochondrial tRNA 3'-end processing →	+0.136	+0.985	<.001	<.001	3	17
BLOOD_Myeloma	DNA replication initiation →	+0.158	+0.999	<.001	.001	3	16
BREAST	tRNA 3'-terminal CCA addition →	+0.140	+0.844	<.001	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,693 associations by consensus.

Protein import into mitochondrial intermembrane space by CHCHD4 expression — BLOOD_Myeloma

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