CHCHD4

Across TCGA cell cohorts, CHCHD4 mutation is significantly associated with the mutation status of many other genes, with 260 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHCHD4-associated genes across cancer lineages are DNAAF6, NUFIP1, and SLC27A5. Each is linked with CHCHD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHCHD4-to-partner and partner-to-CHCHD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAAF6 grouped by CHCHD4-low versus CHCHD4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHCHD4→partner) and Y-score (partner→CHCHD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DNAAF6 →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	NUFIP1 →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	SLC27A5 →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	MGST1 →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	RYBP →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	C1orf50 →	+4.523	+5.087	.006	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 260 associations by consensus.

DNAAF6 by CHCHD4 expression — LARGE_INTESTINE

Explore this box plot interactively →