CHCHD3

Across TCGA pan-cancer cohorts, CHCHD3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CHCHD3 data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CHCHD3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CHCHD3 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where CHCHD3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.912	.013	60	view →
CCRCC	DFS	Median	II,III,IV	0.539	0.860	.002	30	view →
PDAC	OS	Median	III,IV	0.865	0.329	.003	17	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	12	view →
GBM	DFS	Tertile	All	0.834	0.652	.009	11	view →
UCEC	DFS	Quartile	All	0.854	1.000	.043	4	view →
HNSC	DFS	Quartile	II,III,IV	0.866	0.988	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CHCHD3–COAD (DFS)

Open the COAD breakdown →