CHCHD3

Across TCGA pan-cancer cohorts, CHCHD3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CHCHD3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CHCHD3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHCHD3 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRP, LIHC, and LUAD are the cancer types where CHCHD3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHCHD3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.651	<.001	10	view →
LIHC	Female	All	+1.199	<.001	8	view →
LUAD	Male	II,III,IV	+0.563	<.001	7	view →
COAD	All	II,III,IV	+0.386	<.001	7	view →
LUSC	All	All	+0.450	<.001	6	view →
BRCA	All	II,III,IV	+0.378	<.001	6	view →
CHOL	Female	All	+1.906	<.001	5	view →
HNSC	All	II,III,IV	+0.370	.003	5	view →
ESCA	All	All	+0.929	<.001	4	view →
BLCA	All	All	+0.414	.014	4	view →
KICH	All	IV	+0.782	.009	2	view →
STAD	All	II,III,IV	+0.419	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CHCHD3–KIRP

Open the KIRP breakdown →