CHCHD3

Across TCGA patient cohorts, CHCHD3 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHCHD3-associated genes across cancer lineages are Rad50, Gab2, and JNK2. Each is linked with CHCHD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHCHD3-to-partner and partner-to-CHCHD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by CHCHD3-low versus CHCHD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHCHD3→partner) and Y-score (partner→CHCHD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.188	-2.502	.048	.002	3	2
UCEC	Gab2 →	+0.323	+2.000	.021	.010	3	1
UCEC	JNK2 →	+0.239	+2.502	.002	.002	3	1
UCEC	MEK1 →	+0.322	+3.584	.025	.002	3	1
UCEC	p62 Lck ligand →	+0.309	+1.884	.015	.030	3	1
UCEC	Annexin-1 →	+0.452	+2.189	.028	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Rad50 by CHCHD3 expression — UCEC

Explore this box plot interactively →