CHCHD2P6

Across TCGA pan-cancer cohorts, CHCHD2P6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CHCHD2P6’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CHCHD2P6 RNA is repressed in tumor relative to normal tissue. In most cancer types CHCHD2P6 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and COAD are the cancer types where CHCHD2P6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHCHD2P6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.062	<.001	10	view →
KICH	Male	All	−1.380	<.001	9	view →
COAD	Female	II,III,IV	+0.983	<.001	6	view →
LIHC	Female	All	+0.606	<.001	6	view →
HNSC	All	All	+0.437	.001	6	view →
BLCA	All	III,IV	+0.473	.023	4	view →
KIRC	All	All	−0.257	.004	4	view →
CHOL	All	All	+0.545	<.001	3	view →
LUAD	All	All	+0.495	<.001	3	view →
LUSC	Male	All	+0.344	.016	2	view →
PRAD	All	All	−0.249	.018	2	view →
LUSC	Female	III,IV	−1.255	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CHCHD2P6–THCA

Open the THCA breakdown →