CHCHD2

Across TCGA patient cohorts, CHCHD2 protein abundance is significantly associated with the RNA expression of many other genes, with 14,834 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CHCHD2-associated genes across cancer lineages are NIPSNAP2, MRPS17, and SUN1. Each is linked with CHCHD2 in more than 5 cancer types. Because this analysis shows association rather than direction, both CHCHD2-to-partner and partner-to-CHCHD2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHCHD2 versus NIPSNAP2 in HNSC, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHCHD2→partner) and Y-score (partner→CHCHD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NIPSNAP2 →	+0.981	+0.360	<.001	<.001	3	6
HNSC	MRPS17 →	+0.926	+0.472	<.001	<.001	3	6
HNSC	SUN1 →	+0.557	+0.322	<.001	.003	3	6
HNSC	RP9P →	+0.695	+0.266	<.001	.001	3	6
HNSC	SNORA5C →	+0.894	+0.268	.006	.007	3	6
LUAD	POLD2 →	+0.637	+0.342	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,834 associations by consensus.

CHCHD2 vs NIPSNAP2 — HNSC

Explore this scatter interactively →