CHCHD1

Across TCGA pan-cancer cohorts, CHCHD1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CHCHD1 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CHCHD1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CHCHD1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, HNSC, and GBM are the cancer types where CHCHD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.910	0.759	.004	10	view →
HNSC	DFS	Median	III,IV	0.906	1.000	.006	8	view →
GBM	DFS	Median	All	0.439	0.297	.028	5	view →
CCRCC	OS	Median	All	1.000	0.911	.023	5	view →
UCEC	DFS	Quartile	All	0.772	0.971	.027	2	view →
LSCC	DFS	Tertile	II,III,IV	0.848	0.543	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CHCHD1–LUAD (DFS)

Open the LUAD breakdown →