CHAF1B

Across TCGA pan-cancer cohorts, CHAF1B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CHAF1B data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CHAF1B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CHAF1B expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, LSCC, and HNSC are the cancer types where CHAF1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.894	0.417	.003	26	view →
LSCC	OS	Tertile	All	0.940	0.709	.004	25	view →
HNSC	DFS	Quartile	All	0.500	1.000	.036	6	view →
PDAC	DFS	Tertile	II,III,IV	0.936	0.579	.024	2	view →
UCEC	DFS	Median	All	0.795	0.913	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CHAF1B–LUAD (DFS)

Open the LUAD breakdown →