CHAF1A

Across TCGA patient cohorts, CHAF1A mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHAF1A-associated genes across cancer lineages are 4E-BP1, INPP4B, and Mre11. Each is linked with CHAF1A in more than 2 cancer types. Because this analysis shows association rather than direction, both CHAF1A-to-partner and partner-to-CHAF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CHAF1A-low versus CHAF1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAF1A→partner) and Y-score (partner→CHAF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.281	+2.222	.001	.009	3	3
UCEC	INPP4B →	-0.228	-1.906	.032	.014	3	2
UCEC	Mre11 →	-0.055	-2.295	.049	.033	3	2
UCEC	PCNA →	+0.194	+2.000	.006	.029	3	2
UCEC	PDCD4 →	-0.456	-2.405	.003	.003	3	2
UCEC	Rictor_pT1135 →	-0.074	-1.392	.028	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

4E-BP1 by CHAF1A expression — UCEC

Explore this box plot interactively →