CHAF1A

Across TCGA cell cohorts, CHAF1A RNA expression is significantly associated with the go_rna of many other GO terms, with 5,551 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CHAF1A-associated GO terms across cancer lineages are Regulation of DNA-templated DNA replication, Chromosome segregation, and Mitotic chromosome condensation. Each is linked with CHAF1A in more than 19 cancer types. Because this analysis shows association rather than direction, both CHAF1A-to-partner and partner-to-CHAF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated DNA replication grouped by CHAF1A-low versus CHAF1A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHAF1A→partner) and Y-score (partner→CHAF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of DNA-templated DNA replication →	+0.173	+1.959	<.001	<.001	3	20
BONE	Chromosome segregation →	+0.146	+1.954	.001	<.001	3	20
OESOPHAGUS	Mitotic chromosome condensation →	+0.184	+1.008	.001	.001	3	20
BONE	Cell cycle checkpoint signaling →	+0.112	+1.460	<.001	<.001	3	20
STOMACH	Constitutive heterochromatin formation →	+0.121	+1.174	<.001	.002	3	20
BLOOD_Myeloma	Mitotic DNA replication →	+0.214	+1.336	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,551 associations by consensus.

Regulation of DNA-templated DNA replication by CHAF1A expression — BONE

Explore this box plot interactively →