CHADL

Across TCGA patient cohorts, CHADL protein abundance is significantly associated with the RNA expression of many other genes, with 704 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CHADL-associated genes across cancer lineages are PSEN2, SLC1A6, and PDE10A. Each is linked with CHADL in more than 1 cancer types. Because this analysis shows association rather than direction, both CHADL-to-partner and partner-to-CHADL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHADL versus PSEN2 in HNSC, with a Pearson correlation of -0.24.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHADL→partner) and Y-score (partner→CHADL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PSEN2 →	-0.418	-0.443	.008	.008	3	2
HNSC	SLC1A6 →	-0.450	-0.466	.006	.005	3	1
HNSC	PDE10A →	-0.633	-0.696	.001	<.001	3	1
HNSC	PDZD2 →	-0.699	-0.580	.007	.001	3	1
HNSC	MAP2K5 →	-0.475	-0.581	.005	.001	3	1
HNSC	GRB7 →	+0.946	+0.665	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 704 associations by consensus.

CHADL vs PSEN2 — HNSC

Explore this scatter interactively →