CHADL

Across TCGA pan-cancer cohorts, CHADL RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CHADL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CHADL RNA is repressed in tumor relative to normal tissue. In most cancer types CHADL is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and HNSC are the cancer types where CHADL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHADL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−0.650	<.001	11	view →
KICH	Male	All	−1.019	<.001	10	view →
HNSC	All	II,III,IV	−0.724	<.001	10	view →
KIRP	All	III,IV	−1.071	<.001	9	view →
LUAD	All	II,III,IV	−0.651	<.001	8	view →
THCA	Male	IV	−1.446	<.001	6	view →
BRCA	Female	II,III,IV	−0.605	<.001	6	view →
STAD	Female	All	−1.435	<.001	5	view →
LUSC	Male	III,IV	−1.362	<.001	5	view →
COAD	All	II,III,IV	−0.410	.009	3	view →
LIHC	All	All	+0.683	<.001	2	view →
CHOL	All	All	+0.678	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CHADL–KIRC

Open the KIRC breakdown →