CHADL

Across TCGA patient cohorts, CHADL mutation is significantly associated with the RNA expression of many other genes, with 2,505 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHADL-associated genes across cancer lineages are RAB11A, CORO1C, and TTC19. Each is linked with CHADL in more than 1 cancer types. Because this analysis shows association rather than direction, both CHADL-to-partner and partner-to-CHADL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAB11A grouped by CHADL-low versus CHADL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHADL→partner) and Y-score (partner→CHADL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAB11A →	+0.502	+2.700	.002	.006	3	2
UCEC	CORO1C →	+0.808	+3.807	<.001	<.001	3	2
UCEC	TTC19 →	+0.500	+3.807	.006	<.001	3	2
UCEC	PPP2CA →	+0.402	+2.754	.005	.003	3	2
UCEC	PLCD4 →	+0.525	+3.512	<.001	.002	3	2
UCEC	CAPZA1 →	+0.481	+3.850	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,505 associations by consensus.

RAB11A by CHADL expression — UCEC

Explore this box plot interactively →