CHADL

Across TCGA patient cohorts, CHADL mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHADL-associated genes across cancer lineages are JNK2, Notch1, and p62 Lck ligand. Each is linked with CHADL in more than 1 cancer types. Because this analysis shows association rather than direction, both CHADL-to-partner and partner-to-CHADL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by CHADL-low versus CHADL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHADL→partner) and Y-score (partner→CHADL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.287	+2.817	.005	.036	3	1
UCEC	Notch1 →	+0.259	+3.321	<.001	.010	3	1
UCEC	p62 Lck ligand →	+0.442	+3.009	.009	.019	3	1
UCEC	4E-BP1 →	+0.359	+2.837	.011	.035	3	1
UCEC	eIF4E →	+0.223	+3.321	.043	.010	2	1
UCEC	VEGFR2 →	+0.358	+3.335	.021	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

JNK2 by CHADL expression — UCEC

Explore this box plot interactively →