CGB3

Across TCGA patient cohorts, CGB3 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CGB3-associated genes across cancer lineages are RNA5SP414, RNA5SP422, and RNA5SP416. Each is linked with CGB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CGB3-to-partner and partner-to-CGB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by CGB3-low versus CGB3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CGB3→partner) and Y-score (partner→CGB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP414 →	+0.477	+8.471	<.001	.005	3	2
UCEC	RNA5SP422 →	+1.906	+3.671	<.001	.003	3	2
UCEC	RNA5SP416 →	+1.199	+4.224	<.001	.001	3	2
UCEC	RNA5SP411 →	+2.425	+3.393	<.001	.007	3	2
UCEC	RNA5SP410 →	+1.491	+3.789	<.001	.002	3	2
UCEC	RNA5SP413 →	+2.063	+3.277	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

RNA5SP414 by CGB3 expression — BRCA

Explore this box plot interactively →