CGB3

Across TCGA pan-cancer cohorts, CGB3 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CGB3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CGB3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CGB3 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where CGB3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CGB3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.105	<.001	9	view →
KIRC	All	All	−0.015	.004	5	view →
KIRP	All	All	+0.037	.003	4	view →
LUSC	All	All	+0.093	.008	3	view →
STAD	Male	III,IV	+0.093	.028	3	view →
BLCA	All	All	+0.340	.032	2	view →
CHOL	All	All	+0.046	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CGB3–HNSC

Open the HNSC breakdown →