CGB2

Across TCGA patient cohorts, CGB2 mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CGB2-associated genes across cancer lineages are RPL21P66, RNU6-1170P, and RNA5SP437. Each is linked with CGB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CGB2-to-partner and partner-to-CGB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL21P66 grouped by CGB2-low versus CGB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CGB2→partner) and Y-score (partner→CGB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL21P66 →	+0.101	+3.131	.002	.003	3	2
SKCM	RNU6-1170P →	+0.425	+4.563	<.001	.004	3	1
SKCM	RNA5SP437 →	+0.353	+4.241	<.001	.008	3	1
SKCM	MIR4261 →	+0.711	+4.188	<.001	.009	3	1
UCEC	STARD6 →	+0.279	+3.746	<.001	.002	3	1
BRCA	MTCYBP2 →	+0.184	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

RPL21P66 by CGB2 expression — UCEC

Explore this box plot interactively →