CGAS

Across TCGA cell cohorts, CGAS RNA expression is significantly associated with the go_rna of many other GO terms, with 4,946 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CGAS-associated GO terms across cancer lineages are Urokinase plasminogen activator signaling pathway, Cellular response to external stimulus, and Cellular response to mechanical stimulus. Each is linked with CGAS in more than 12 cancer types. Because this analysis shows association rather than direction, both CGAS-to-partner and partner-to-CGAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Urokinase plasminogen activator signaling pathway grouped by CGAS-low versus CGAS-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CGAS→partner) and Y-score (partner→CGAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Urokinase plasminogen activator signaling pathway →	+1.389	+1.866	<.001	<.001	3	13
OVARY	Cellular response to external stimulus →	+0.108	+2.345	<.001	<.001	3	12
OVARY	Cellular response to mechanical stimulus →	+0.106	+2.173	<.001	<.001	3	11
STOMACH	Pattern recognition receptor signaling pathway →	+0.072	+1.927	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Cytoplasmic pattern recognition receptor signaling pathway →	+0.075	+1.042	.001	.004	3	10
UPPER_AERODIGESTIVE_TRACT	Innate immune response-activating signaling pathway →	+0.073	+1.073	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,946 associations by consensus.

Urokinase plasminogen activator signaling pathway by CGAS expression — BREAST

Explore this box plot interactively →