CGAS

Across TCGA cell cohorts, CGAS mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible CGAS-associated genes across cancer lineages are PRAMEF9, GSG1L2, and RASGEF1C. Each is linked with CGAS in more than 1 cancer types. Because this analysis shows association rather than direction, both CGAS-to-partner and partner-to-CGAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF9 grouped by CGAS-low versus CGAS-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CGAS→partner) and Y-score (partner→CGAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PRAMEF9 →	+0.013	+5.087	<.001	.004	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1
LARGE_INTESTINE	RASGEF1C →	+0.213	+3.333	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PRAMEF9 by CGAS expression — URINARY_TRACT

Explore this box plot interactively →