CFTR

Across TCGA patient cohorts, CFTR protein abundance is significantly associated with the RNA expression of many other genes, with 8,013 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CFTR-associated genes across cancer lineages are COL4A2, GUCY1A2, and PODN. Each is linked with CFTR in more than 2 cancer types. Because this analysis shows association rather than direction, both CFTR-to-partner and partner-to-CFTR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CFTR versus COL4A2 in LSCC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFTR→partner) and Y-score (partner→CFTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	COL4A2 →	+1.006	+0.888	<.001	<.001	3	3
LSCC	GUCY1A2 →	+1.268	+1.024	<.001	<.001	3	3
BRCA	PODN →	+1.488	+1.295	.002	.001	3	3
CCRCC	THBS2 →	+1.543	+0.740	.002	<.001	3	3
CCRCC	COL14A1 →	+1.071	+0.749	.001	<.001	3	3
LSCC	KCNQ1 →	+0.571	+0.593	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,013 associations by consensus.

CFTR vs COL4A2 — LSCC

Explore this scatter interactively →