CFTR

Across TCGA pan-cancer cohorts, CFTR RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CFTR’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CFTR RNA is repressed in tumor relative to normal tissue. In most cancer types CFTR is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and KIRC are the cancer types where CFTR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CFTR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	−1.563	<.001	12	view →
LUAD	Male	III,IV	−3.078	<.001	11	view →
KIRC	Female	III,IV	−1.102	<.001	11	view →
LUSC	Male	II,III,IV	−3.068	<.001	8	view →
KICH	Male	All	+5.090	<.001	7	view →
BRCA	All	III,IV	−0.453	<.001	6	view →
LIHC	Male	III,IV	−1.387	<.001	5	view →
KIRP	Male	II,III,IV	−0.598	.004	4	view →
THCA	Male	IV	+0.426	.016	4	view →
STAD	All	All	+1.242	.006	3	view →
ESCA	All	All	+2.455	.036	1	view →
CHOL	All	All	+2.017	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CFTR–HNSC

Open the HNSC breakdown →