CFTR

Across TCGA patient cohorts, CFTR mutation is significantly associated with the RNA expression of many other genes, with 4,780 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFTR-associated genes across cancer lineages are C1orf174, PSMA1, and XPNPEP1. Each is linked with CFTR in more than 4 cancer types. Because this analysis shows association rather than direction, both CFTR-to-partner and partner-to-CFTR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf174 grouped by CFTR-low versus CFTR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFTR→partner) and Y-score (partner→CFTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C1orf174 →	+0.275	+1.592	.004	.002	3	5
UCEC	PSMA1 →	+0.281	+1.479	.007	.001	3	5
UCEC	XPNPEP1 →	+0.404	+2.402	<.001	<.001	3	4
UCEC	SNRNP40 →	+0.377	+1.793	.008	.001	3	4
UCEC	CDCA2 →	+0.728	+1.830	<.001	<.001	3	4
UCEC	MCMBP →	+0.398	+1.980	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,780 associations by consensus.

C1orf174 by CFTR expression — UCEC

Explore this box plot interactively →