CFTR

Across TCGA cell cohorts, CFTR RNA expression is significantly associated with the go_rna of many other GO terms, with 2,360 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CFTR-associated GO terms across cancer lineages are Transepithelial water transport, Regulation of enamel mineralization, and Positive regulation of enamel mineralization. Each is linked with CFTR in more than 6 cancer types. Because this analysis shows association rather than direction, both CFTR-to-partner and partner-to-CFTR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transepithelial water transport grouped by CFTR-low versus CFTR-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CFTR→partner) and Y-score (partner→CFTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Transepithelial water transport →	+1.704	+3.593	<.001	<.001	3	7
LIVER	Regulation of enamel mineralization →	-0.233	-1.399	<.001	<.001	3	6
LIVER	Positive regulation of enamel mineralization →	-0.223	-1.304	<.001	<.001	3	6
LIVER	Regulation of syncytium formation by plasma membrane fusion →	+0.075	+1.271	.001	.006	3	6
LIVER	Regulation of myoblast fusion →	+0.088	+1.168	<.001	.008	3	6
LARGE_INTESTINE	Monocarboxylic acid catabolic process →	+0.053	+2.380	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,360 associations by consensus.

Transepithelial water transport by CFTR expression — LARGE_INTESTINE

Explore this box plot interactively →