CFTR

Across TCGA cell cohorts, CFTR mutation is significantly associated with the RNA expression of many other genes, with 441 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CFTR-associated genes across cancer lineages are MMP26, RTP2, and DMRTB1. Each is linked with CFTR in more than 2 cancer types. Because this analysis shows association rather than direction, both CFTR-to-partner and partner-to-CFTR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by CFTR-low versus CFTR-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFTR→partner) and Y-score (partner→CFTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MMP26 →	+0.068	+4.169	<.001	.002	3	3
SOFT_TISSUE	RTP2 →	+0.035	+4.169	<.001	.002	3	2
LUNG_NSCLC_LUAD	DMRTB1 →	+0.003	+2.887	<.001	.009	3	2
LUNG_SCLC	OR5C1 →	+0.059	+3.256	<.001	.005	3	2
BLOOD_Myeloma	DMRTA2 →	+0.095	+3.906	.009	.009	3	1
BLOOD_Myeloma	TGM7 →	+0.063	+3.906	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 441 associations by consensus.

MMP26 by CFTR expression — SOFT_TISSUE

Explore this box plot interactively →