CFP

Across TCGA patient cohorts, CFP mutation is significantly associated with the RNA expression of many other genes, with 3,077 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFP-associated genes across cancer lineages are TRIM43B, RN7SL149P, and GRAMD4P6. Each is linked with CFP in more than 1 cancer types. Because this analysis shows association rather than direction, both CFP-to-partner and partner-to-CFP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM43B grouped by CFP-low versus CFP-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFP→partner) and Y-score (partner→CFP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRIM43B →	+0.437	+3.654	<.001	.009	3	2
HNSC	RN7SL149P →	+0.116	+3.881	.007	.006	3	2
HNSC	GRAMD4P6 →	+0.296	+6.781	<.001	<.001	3	2
LUSC	CNTNAP3P5 →	+0.094	+5.031	<.001	.002	3	2
HNSC	RNA5SP241 →	+0.337	+5.497	<.001	<.001	3	2
BRCA	MEP1AP4 →	+0.033	+4.527	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,077 associations by consensus.

TRIM43B by CFP expression — HNSC

Explore this box plot interactively →