CFP

Across TCGA cell cohorts, CFP mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CFP-associated genes across cancer lineages are MSGN1, OR10A4, and OR4F21. Each is linked with CFP in more than 1 cancer types. Because this analysis shows association rather than direction, both CFP-to-partner and partner-to-CFP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by CFP-low versus CFP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFP→partner) and Y-score (partner→CFP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	OR10A4 →	+0.056	+3.938	.001	.002	3	1
LARGE_INTESTINE	OR4F21 →	+0.198	+3.878	<.001	.003	3	1
LARGE_INTESTINE	C14orf180 →	+0.168	+3.155	<.001	.008	3	1
LARGE_INTESTINE	LCN8 →	+0.160	+3.125	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MSGN1 by CFP expression — LARGE_INTESTINE

Explore this box plot interactively →