Across TCGA cell cohorts, CFI mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CFI-associated genes across cancer lineages are CCR8, GK2, and IFNA4. Each is linked with CFI in more than 1 cancer types. Because this analysis shows association rather than direction, both CFI-to-partner and partner-to-CFI results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFI→partner) and Y-score (partner→CFI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CCR8 →	+0.031	+3.345	<.001	.007	3	2
CNS	GK2 →	+0.006	+5.754	.002	.002	3	1
CNS	IFNA4 →	+0.215	+5.321	<.001	.005	3	1
BLOOD_Leukemia	PRKAG3 →	+0.022	+2.644	<.001	.008	3	1
BLOOD_Leukemia	ZP4 →	+0.006	+3.539	<.001	.002	3	1
BLOOD_Leukemia	GIPC2 →	+0.477	+3.955	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Exploration

CFI survival (RNA) · tumor vs normal (RNA) · all CFI data types