CFHR5

Across TCGA cell cohorts, CFHR5 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CFHR5-associated genes across cancer lineages are OR7A10, LEFTY2, and CRYGD. Each is linked with CFHR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CFHR5-to-partner and partner-to-CFHR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7A10 grouped by CFHR5-low versus CFHR5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFHR5→partner) and Y-score (partner→CFHR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR7A10 →	+0.014	+4.437	<.001	.004	3	1
SKIN	LEFTY2 →	+0.057	+4.199	<.001	.007	3	1
BLOOD_Lymphoma	CRYGD →	+0.047	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	MMP26 →	+0.056	+5.643	.001	.002	3	1
BLOOD_Lymphoma	C14orf180 →	+0.015	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	PNMA6F →	+0.013	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR7A10 by CFHR5 expression — SKIN

Explore this box plot interactively →