CFHR2

Across TCGA patient cohorts, CFHR2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFHR2-associated genes across cancer lineages are YAP_pS127, Chk1, and YAP. Each is linked with CFHR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CFHR2-to-partner and partner-to-CFHR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YAP_pS127 grouped by CFHR2-low versus CFHR2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFHR2→partner) and Y-score (partner→CFHR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	YAP_pS127 →	-0.284	-1.857	.033	.047	3	2
SKCM	Chk1 →	+0.188	+2.235	.008	.005	3	2
LUSC	YAP →	+0.261	+2.816	.023	.036	2	2
LUSC	Dvl3 →	+0.236	+2.816	.028	.036	3	1
SKCM	HER3 →	+0.408	+3.169	.008	.017	3	1
SKCM	MYH11 →	-0.862	-2.584	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

YAP_pS127 by CFHR2 expression — SKCM

Explore this box plot interactively →