CFHR2

Across TCGA cell cohorts, CFHR2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CFHR2-associated genes across cancer lineages are USP29, DEFB125, and ENPP7. Each is linked with CFHR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CFHR2-to-partner and partner-to-CFHR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP29 grouped by CFHR2-low versus CFHR2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFHR2→partner) and Y-score (partner→CFHR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	USP29 →	+0.009	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	DEFB125 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	ENPP7 →	+0.174	+4.347	<.001	.001	3	1
LUNG_NSCLC_LUAD	RESP18 →	+0.019	+3.947	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.011	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	RGS21 →	+0.014	+4.189	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

USP29 by CFHR2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →