CFHR1

Across TCGA cell cohorts, CFHR1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CFHR1-associated genes across cancer lineages are SH3GL2, RASGEF1C, and TAFA1. Each is linked with CFHR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CFHR1-to-partner and partner-to-CFHR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by CFHR1-low versus CFHR1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFHR1→partner) and Y-score (partner→CFHR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.111	+3.252	.005	.009	3	1
LARGE_INTESTINE	RASGEF1C →	+0.230	+3.626	.002	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.201	+2.688	.005	.008	3	1
LARGE_INTESTINE	ADH1B →	+0.043	+2.989	.004	.003	3	1
LARGE_INTESTINE	BPIFA1 →	+0.102	+3.425	.005	<.001	3	1
LARGE_INTESTINE	ANKRD63 →	+0.303	+3.963	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

SH3GL2 by CFHR1 expression — LARGE_INTESTINE

Explore this box plot interactively →