CFH

Across TCGA pan-cancer cohorts, CFH mass-spec protein is linked to patient survival in 9 of 34 cancer types, making it a survival-associated CFH data layer compared with 20 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CFH mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CFH expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

LUAD, LSCC, and COAD are the cancer types where CFH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.321	0.823	.001	32	view →
LSCC	DFS	Median	II,III,IV	0.830	1.000	.003	15	view →
COAD	DFS	Tertile	II,III,IV	0.864	1.000	.042	12	view →
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.005	12	view →
UCEC	DFS	Tertile	III,IV	0.366	1.000	.020	10	view →
GBM	OS	Tertile	All	0.278	0.522	.021	7	view →
OV	DFS	Median	All	1.000	0.867	.040	4	view →
PDAC	OS	Quartile	III,IV	0.325	1.000	.040	4	view →
HNSC	DFS	Median	II,III,IV	0.556	0.726	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

CFH–LUAD (OS)

Open the LUAD breakdown →