CFH

Across TCGA pan-cancer cohorts, CFH RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CFH’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CFH RNA is repressed in tumor relative to normal tissue. In most cancer types CFH is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and BLCA are the cancer types where CFH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CFH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−2.656	<.001	9	view →
COAD	Female	II,III,IV	−1.223	<.001	9	view →
BLCA	All	All	−1.388	<.001	7	view →
BRCA	All	III,IV	−1.056	<.001	6	view →
CHOL	Male	All	−3.625	<.001	5	view →
THCA	Female	All	−0.958	.002	5	view →
LUSC	All	All	−0.666	.002	5	view →
KIRC	All	All	+0.573	.003	4	view →
READ	Female	All	−1.822	<.001	2	view →
PAAD	All	All	+1.660	.030	2	view →
PRAD	All	All	−0.895	<.001	2	view →
HNSC	Male	IV	−1.169	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CFH–KICH

Open the KICH breakdown →