CFH

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CFH RNA expression is significantly associated with the protein abundance of many other proteins, with 21,101 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CFH-associated proteins across cancer lineages are DCN, F13A1, and TBC1D2B. Each is linked with CFH in more than 8 cancer types. Because this analysis shows association rather than direction, both CFH-to-partner and partner-to-CFH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CFH versus DCN in GBM, with a Pearson correlation of 0.53.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CFH→partner) and Y-score (partner→CFH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMDCN →+1.519+1.800<.001<.00139
GBMF13A1 →+1.071+1.258<.001<.00139
OVTBC1D2B →+0.330+1.539<.001<.00139
OVOLFML3 →+0.929+1.337<.001<.00138
OVPALLD →+0.814+1.276<.001<.00138
OVFKBP7 →+0.630+1.510<.001<.00138
Each partner links to its Q-omics profile. Showing the 6 strongest of 21,101 associations by consensus.

CFH vs DCN — GBM

Per-sample scatter of CFH vs DCN in GBM (Pearson r = 0.53).

Explore this scatter interactively →

Exploration