CFH

Across TCGA patient cohorts, CFH mutation is significantly associated with the RNA expression of many other genes, with 6,416 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFH-associated genes across cancer lineages are SASS6, CENPE, and CCNA2. Each is linked with CFH in more than 4 cancer types. Because this analysis shows association rather than direction, both CFH-to-partner and partner-to-CFH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SASS6 grouped by CFH-low versus CFH-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFH→partner) and Y-score (partner→CFH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SASS6 →	+0.491	+3.392	.001	<.001	3	5
UCEC	CENPE →	+0.569	+1.721	<.001	<.001	3	4
UCEC	CCNA2 →	+0.656	+1.721	<.001	<.001	3	4
COAD	ADAM33 →	-0.582	-3.787	.002	<.001	3	4
LUAD	KIF15 →	+0.592	+3.392	.003	<.001	3	4
UCEC	AIMP1 →	+0.413	+2.191	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,416 associations by consensus.

SASS6 by CFH expression — LUAD

Explore this box plot interactively →