CFH

Across TCGA patient cohorts, CFH mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CFH-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and eIF4E. Each is linked with CFH in more than 4 cancer types. Because this analysis shows association rather than direction, both CFH-to-partner and partner-to-CFH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CFH-low versus CFH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFH→partner) and Y-score (partner→CFH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.234	+3.338	<.001	.004	3	5
UCEC	ATM →	-0.520	-3.986	<.001	<.001	3	5
COAD	eIF4E →	+0.247	+3.182	<.001	.009	3	4
LUSC	PCNA →	+0.144	+1.424	.046	.028	3	4
UCEC	Cyclin-B1 →	+0.501	+1.999	.002	.002	3	4
COAD	FASN →	+0.494	+2.584	.001	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

Caspase-7-cleavedD198 by CFH expression — COAD

Explore this box plot interactively →