CFH

Across TCGA cell cohorts, CFH mutation is significantly associated with the RNA expression of many other genes, with 333 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CFH-associated genes across cancer lineages are OR6C70, CCNC, and TPO. Each is linked with CFH in more than 1 cancer types. Because this analysis shows association rather than direction, both CFH-to-partner and partner-to-CFH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6C70 grouped by CFH-low versus CFH-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFH→partner) and Y-score (partner→CFH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR6C70 →	+0.020	+4.058	<.001	.007	3	2
LARGE_INTESTINE	CCNC →	+0.504	+3.169	.003	.006	3	2
LARGE_INTESTINE	TPO →	+0.188	+2.474	.004	.004	3	2
LARGE_INTESTINE	HS6ST1 →	+0.785	+3.389	.003	.001	3	2
LARGE_INTESTINE	MARCHF5 →	+0.681	+3.459	<.001	.001	3	2
OESOPHAGUS	LILRA1 →	+0.006	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 333 associations by consensus.

OR6C70 by CFH expression — LUNG_SCLC

Explore this box plot interactively →