CFAP251

Across TCGA cell cohorts, CFAP251 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CFAP251-associated genes across cancer lineages are MINAR2, DEFB118, and OR5B12. Each is linked with CFAP251 in more than 1 cancer types. Because this analysis shows association rather than direction, both CFAP251-to-partner and partner-to-CFAP251 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MINAR2 grouped by CFAP251-low versus CFAP251-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CFAP251→partner) and Y-score (partner→CFAP251) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MINAR2 →	+0.066	+4.736	<.001	.009	3	2
LUNG_NSCLC_LUAD	DEFB118 →	+0.010	+5.266	<.001	.001	3	1
CNS	OR5B12 →	+0.014	+4.044	<.001	.003	3	1
CNS	PRM3 →	+0.104	+4.169	<.001	.008	3	1
CNS	LRRC72 →	+0.013	+4.169	<.001	.008	3	1
OVARY	IL36A →	+0.133	+3.990	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MINAR2 by CFAP251 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →